Target-selective photo-degradation of HIV-1 protease by a fullerene-sugar hybrid.
نویسندگان
چکیده
A designed fullerene-sugar hybrid effectively and selectively degraded the target protein, HIV-1 protease, which has high affinity for the fullerene moiety; degradation was achieved using long-wavelength UV or visible photo-irradiation, in the absence of any additives and under neutral conditions.
منابع مشابه
Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson-Boltzmann surface area calculations
The objectives of this study include the design of a series of novel fullerene-based inhibitors for HIV-1 protease (HIV-1 PR), by employing two strategies that can also be applied to the design of inhibitors for any other target. Additionally, the interactions which contribute to the observed exceptionally high binding free energies were analyzed. In particular, we investigated: (1) hydrogen bo...
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عنوان ژورنال:
- Chemical communications
دوره 44 شماره
صفحات -
تاریخ انتشار 2008